There is concern about early prophylaxis with indomethacin since some infants might be exposed to an unnecessary agent if the ductus would have closed on its own. however, Delaying treatment until one can document that the PDA is unlikely to undergo spontaneous closure may increase the infant's chances of developing morbidities caused by the PDA and make the success of pharmacological closure less likely. blog is going to review both the published evidence and the experience in the management of PDA.surface of pagePathophysiologyIn utero, Low fetal endemic arterial oxygen tension (PaO2) And elevated distributed PGs (as well as PGs made within the ductus wall itself) Play a life threatening role in keeping the lumen of the ductus arteriosus patent.
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